Back Drucker, DJ, Mojsov, S, Habener, JF (25 July 1986) 'Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene', Journal Biological Chemistry , 261/21, 9637-43
It has no estrogenic activity but does possess high progestogenic activity
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Sex differences in psychiatric disorders have long been recognised : the Val(158)Met polymorphism in COMT is associated with obsessive-compulsive disorder in men, with anxiety phenotypes in women, and has a greater impact on cognitive function in boys than girls with COMT activity, on average, being lower in women than men due partly to its suppression by estrogen (Harrison, Tunbridge, 2008)